Executive Summary
Vertex Pharmaceuticals delivered impressive financial results for Q4 2024, with total revenue reaching $2.91 billion, an increase of 16% compared to Q4 2023, and a record full-year revenue of $11.02 billion, up 12% from the previous year. This year's growth was primarily fueled by a robust performance in the cystic fibrosis (CF) sector, aided by the successful launch of the new medication ALYFTREK. Additionally, the newly approved JOURNAVX offers Vertex a solid entry into the non-opioid pain management market, potentially enhancing patient accessibility and addressing the opioid crisis. Management views this as a pivotal year for diversifying revenue streams and expanding patient reach.
Key Performance Indicators
QoQ: -12.67% | YoY:-5.76%
QoQ: -12.35% | YoY:-5.59%
Key Insights
**Revenue:** $2.91 billion (up 16% YoY)
**Cost of Revenue:** $423.4 million
**Gross Profit:** $2.49 billion (Gross Profit Margin: 85.5%)
**Operating Income:** $1.03 billion (Operating Income Margin: 35.2%)
**Net Income:** $913 million (Net Income Margin: 31.4%)
**EPS:** $3.55 (Diluted EPS: $3.50)
**Cash at Year-End:** $4.57 billion
The notable increase in revenue was backed by a 17% growth in U.S. sales, attributed to strong market demand and a price increase implemented in January 2024. Managem...
Financial Highlights
Revenue: $2.91 billion (up 16% YoY)
Cost of Revenue: $423.4 million
Gross Profit: $2.49 billion (Gross Profit Margin: 85.5%)
Operating Income: $1.03 billion (Operating Income Margin: 35.2%)
Net Income: $913 million (Net Income Margin: 31.4%)
EPS: $3.55 (Diluted EPS: $3.50)
Cash at Year-End: $4.57 billion
The notable increase in revenue was backed by a 17% growth in U.S. sales, attributed to strong market demand and a price increase implemented in January 2024. Management highlighted the company's ability to exceed revenue guidance and the importance of newly launched products in diversifying its revenue base.
Income Statement
| Metric |
Value |
YoY Change |
QoQ Change |
| Revenue |
2.91B |
15.66% |
5.05% |
| Gross Profit |
2.49B |
15.76% |
4.59% |
| Operating Income |
1.03B |
7.01% |
-8.09% |
| Net Income |
913.00M |
-5.76% |
-12.67% |
| EPS |
3.55 |
-5.59% |
-12.35% |
Key Financial Ratios
operatingProfitMargin
35.2%
operatingCashFlowPerShare
$2.27
freeCashFlowPerShare
$1.91
Management Commentary
On Product Launches: "The continued outstanding commercial execution in CF helped us drive double-digit revenue growth for our 10th consecutive year... The launch of CASGEVY set us on the course of revenue diversification." - Dr. Reshma Kewalramani
On Future Product Pipeline: "We seek to serve more than 5 million more patients, including... type 1 diabetes and certain renal diseases, and then another 10 million plus patients with peripheral neuropathic pain in the U.S. alone." - Dr. Reshma Kewalramani
On JOURNAVX: "We have the opportunity to transform how acute pain is treated in the U.S. and to build another multi-billion dollar franchise for Vertex." - Stuart Arbuckle
These insights underline the companyβs positive momentum and strategic direction towards expanding its therapeutic portfolio.
"We are focused on driving a significant expansion in the patients we serve with the ongoing launch of CASGEVY and two recent U.S. NDA approvals: ALYFTREK... and JOURNAVX." - Dr. Reshma Kewalramani
β Dr. Reshma Kewalramani
"The business has never been in a better position scientifically and commercially than we are today." - Stuart Arbuckle
β Stuart Arbuckle
Forward Guidance
Management provided guidance for 2025, expecting total revenue between $11.75 billion and $12 billion, representing approximately 8% growth. The guidance reflects anticipated continued growth from existing CF medicines, the ramp-up of CASGEVY and new contributions from JOURNAVX in the latter half of the year. Management believes that the benefit from the lower royalty burden on ALYFTREK will facilitate profitability, although it notes that production costs on scaling up other products may offset this benefit.