Executive Summary
Pluri Inc reported QQ1 2025 results showing a modest top-line progress at USD 326k with a gross margin of approximately 61.3%, but the quarter remained deeply unprofitable as R&D and SG&A investments continued to drive a substantial operating and net loss. Despite a strong gross margin, the company logged an EBITDA of –5.754 million and a net income of –5.882 million, reflecting a robust burn typical for early-stage biotech platforms prioritizing platform development and large-scale Phase III programs. On the balance sheet, Pluri maintains a sizable cash position and liquid investments (USD 25.66 million in cash and short-term investments) but carries a heavy long-term debt burden (USD 30.30 million) and negative stockholders’ equity (USD –5.28 million), resulting in leveraged financials and a relatively tight cash runway absent new financing or milestone-driven inflows.
Key takeaways for investors include: (1) revenue growth on a YoY basis appears strong in percentage terms due to a low base prior year, yet absolute quarterly revenue remains very small, underscoring the company’s status as a development-stage biotech with no meaningful product sales yet; (2) operating and net losses persist, driven by R&D intensity and G&A, limiting near-term profitability but potentially improving if PLXPAD phase III readouts or collaborations accelerate; (3) liquidity metrics show solid coverage of near-term liabilities (current ratio ~5.9) but leverage remains high, with a debt-to-capitalization exposure that warrants monitoring for future funding needs; and (4) the absence of formal forward guidance and a lack of disclosed transcript-derived management color necessitate reliance on pipeline milestones, trial progress, and capital markets access as primary near-term catalysts.
Key Performance Indicators
QoQ: 239.58% | YoY:503.70%
QoQ: 545.16% | YoY:103.76%
QoQ: -2.67% | YoY:-2 208.24%
QoQ: -5.66% | YoY:-16.67%
Key Insights
Revenue: USD 326 thousand; YoY revenue growth: 503.7%; QoQ revenue growth: 239.6%
Gross Profit: USD 200 thousand; Gross Margin: 61.3%
Operating Expenses: USD 5.901 million; EBITDA: USD –5.754 million; Operating Income: USD –5.701 million; Operating Margin: –17.49%
Net Income: USD –5.882 million; Net Margin: –18.04%; EPS: –1.12; Weighted Avg Shares: 5.240 million
Cash Flow: Net cash from operating activities USD –4.064 million; Free cash flow USD –4.272 million
Liquidity/Capital: ...
Financial Highlights
Revenue: USD 326 thousand; YoY revenue growth: 503.7%; QoQ revenue growth: 239.6%
Gross Profit: USD 200 thousand; Gross Margin: 61.3%
Operating Expenses: USD 5.901 million; EBITDA: USD –5.754 million; Operating Income: USD –5.701 million; Operating Margin: –17.49%
Net Income: USD –5.882 million; Net Margin: –18.04%; EPS: –1.12; Weighted Avg Shares: 5.240 million
Cash Flow: Net cash from operating activities USD –4.064 million; Free cash flow USD –4.272 million
Liquidity/Capital: Cash & ST Investments USD 25.659 million; Cash at end USD 4.216 million; Total assets USD 35.442 million; Total liabilities USD 35.505 million; Long-term debt USD 30.303 million; Net debt USD 27.679 million; Current ratio 5.90; Quick ratio 5.90; Cash ratio 0.698
Valuation/Leverage: Debt/Equity leverage substantial; Total Debt USD 30.877 million; Accumulated deficit USD –426.354 million; Stockholders’ equity USD –5.283 million; P/S 102.58x; P/BV negative; EV/EBITDA not meaningful given negative EBITDA
Income Statement
| Metric |
Value |
YoY Change |
QoQ Change |
| Revenue |
326.00K |
503.70% |
239.58% |
| Gross Profit |
200.00K |
103.76% |
545.16% |
| Operating Income |
-5.70M |
48.76% |
5.52% |
| Net Income |
-5.88M |
-2 208.24% |
-2.67% |
| EPS |
-1.12 |
-16.67% |
-5.66% |
Key Financial Ratios
operatingProfitMargin
-1594%
operatingCashFlowPerShare
$-0.74
freeCashFlowPerShare
$-0.78
Management Commentary
No management transcript data provided in the input. Consequently, there are no transcript highlights to summarize or quote from management. This section will reflect the data availability constraint rather than a negative assessment of management performance.
Forward Guidance
No formal forward guidance was disclosed in the provided data. Given the company’s early-stage biology platform and ongoing Phase III trials for PLXPAD (muscle recovery post-hip fracture and steroid-refractory GVHD) as well as development programs like PLXR18, the key forward-looking considerations are: (1) trial progression milestones and readouts for PLXPAD Phase III programs; (2) ability to secure strategic collaborations, licensing deals, or milestone payments to fund ongoing burn and CAPEX; (3) the scale and timing of any financings to bridge liquidity given the substantial long-term debt burden; (4) regulatory hurdles and potential early interim data readouts that could de-risk the platform. Investors should monitor: enrollment pace, trial completions, regulatory communications, potential partnerships with NIH/DoD or academic centers, and any updates to cost structure or cash burn forecasts. Overall, the path to sustained profitability hinges on successful Phase III outcomes, non-dilutive or modestly dilutive financing, and optionality from licensing milestones.